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Can methotrexate be used as a steroid sparing agent in the treatment of polymyalgia rheumatica and giant cell arteritis? It is important to note that although the use of methotrexate during pregnancy is supported by clinical evidence, it does not appear to be effective in treating the conditions listed below. In summary, there is currently no evidence that methotrexate may be of benefit in improving the clinical status of individuals with these conditions, although it may improve the quality of life. Methotrexate should be started as soon as symptoms develop in the early stages of the disease and treated effectively for at least 3 weeks in a 12-week open-label phase. Adjunctive therapy is not indicated if treatment is being given for the prevention of or relief of the disease process. The main benefit is that the benefit is well tolerated and appears to be dose dependent. Methotrexate used in the treatment of giant cell arteritis may be effective in reducing the number of large blood vessels in the disease process. In the future, it seems worth considering whether the benefits of this drug be further examined. Methotrexate has also been used in combination with antifungal medications. It has also been used in antivenin therapy for the treatment of blood loss to other causes of venous occlusions. Methotrexate has been used in the treatment of atrial fibrillation. In one retrospective study, patients taking methotrexate had significantly fewer myocardial infarction occurring in their patients of all ages than those who were not given methotrexate [ 9 ]. A meta-analysis of placebo controlled trials of atrial fibrillation with methotrexate showed a statistically significant reduction in the rate of severe atrial fibrillation in combination with antifungal medication in adults with no current or prior history of cardiovascular or cerebrovascular disease [ 10 ]. However, in patients requiring antivenin, the benefit was minimal. Methotrexate use in combination with antivenin has not been studied in patients with other conditions for whom antifungal medications are contraindicated. Some side effects have been reported, including dry mouth, drowsiness and sedation. These side effects have not been reported in patients with the above conditions or when methotrexate is combined with other types of treatment. Methotrexate is a long acting medication with very little side effects and should not be given without medical advice. There is no evidence to suggest that the use of methotrexate can cause any harm. The most common adverse reaction that is reported to the Similar articles: